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Health

14 best ‘Botox in a bottle’ anti-wrinkle serums that really work according to our testers

Samatha Menjivar
Last updated: April 23, 2025 3:16 pm
Samatha Menjivar
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14 best ‘Botox in a bottle’ anti-wrinkle serums that really work according to our testers
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Fine lines and wrinkles are two of the most common signs of skin ageing – and for many, also two of the most common skin bugbears, with shoppers clearly regularly on the lookout for the best wrinkle fillers that really work.

In recent years there has been a wave of products that claim to work magic specifically on wrinkles and lines, with results visible either instantly or over a few weeks of use. To see which really deliver on their claims, we tested out a batch of these line-erasing magic creams, from a smart ‘Botox in a bottle’ treatment to a bargain £3.79 face mask – and even better, loads of them are currently on sale. Here are the ones that we deem the best products for deep winkles, that really work…

READ MORE: ‘This new “Botox in a bottle” serum is the best I’ve tried for smooth and glowing skin’

READ MORE: 12 best skin tints and sheer foundations our beauty editors call ‘love at first swipe’

Best wrinkle fillers to buy in 2025

  • Dr Dennis Gross DermInfusions Fill + Repair Eye Cream: £64 from Cult Beauty

  • Medik8 Liquid Peptides Advanced MP: £79 from Medik8

  • SkinCeuticals P-Tiox Neuro-Peptide Serum: £130 from LookFantastic

  • RoC Derm Correxion Fill + Treat Serum: £39.99 from Sephora
  • Hada Labo Tokyo Wrinkle Corrector Eye and Mouth Cream: Was £18.99, now £14.22 from Superdrug
  • No7 Laboratories Line Correcting Booster Serum: £34.95 from Boots
  • Elemis Pro-Collagen Morning Matrix: £128 from LookFantastic
  • L’Oréal Paris 1.5% Hyaluronic Acid Revitalift Filler Serum: Was £24.99, now £19.99 from LookFantastic

  • Nivea Q10 Targeted Wrinkle Filler Serum: Was £14.99 now £7.50 from Amazon

  • Murad Targeted Wrinkle Corrector: £76 from Murad

  • Nivea Expert Lift Cellular Sculpting Sheet Mask: Was £4.99, now £3.79 from Amazon

  • Vichy Liftactiv Supreme HA Epidermic Filler: Was £43, now £32.25 from Boots

  • Dior Capture Totale Retishot: £92 from Dior

  • Luna Microcare Eternal Anti-Wrinkle Under Eye Patches: From £20 from Luna Microcare

Dr Dennis Gross DermInfusions Fill + Repair Eye Cream

£64 from Cult Beauty

This new eye cream is designed to target six zones around the eye area where signs of ageing typically occur – crow’s feet, under eyes, lids, bunny lines, eleven lines and the inner tear trough. It uses trending skincare ingredients copper peptides and ectoin to ‘diminish fines lines, restore the moisture barrier and firm wrinkles’, the brand claims.



Dr Dennis Gross DermInfusions Fill + Repair Eye Cream

Targets six different areas around the eyes
(Image: Dr Dennis Gross)

One Space NK shopper wrote: “I’ve only been using the Fill Repair Eye Cream for a couple of weeks, but I can already see a difference. My under-eyes look more awake and less sunken, and the fine lines are definitely softer. It has a lightweight, silky texture that absorbs quickly and layers well with other products. I love the cooling feel when I apply it – it’s super refreshing in the morning.

“The hyaluronic acid really plumps up the skin, and I’ve noticed less puffiness and darkness overall. It honestly feels like a mini filler effect without the needles!”

Medik8 Liquid Peptides Advanced MP

£79 from Medik8

This serum is currently taking the beauty world by storm with its promise of diminishing deep-set wrinkles in eight weeks and showing visible results in as little as 10 minutes. Customers are already singing its praises, claiming it “really works” and dubbing it “magic in a bottle”.



Laura holding Medik8 Advanced Peptides Serum

Laura has been putting this new Medik8 serum to the test
(Image: Laura Mulley)

OK’s beauty editor Laura says: “From the get-go, the serum impressed me with its elegant formulation. It absorbed swiftly without leaving a greasy residue, played nicely with my other skincare essentials, and stayed put under my make-up without any pilling or sliding.

“My skin felt instantly smoother after using this, and when I checked back in 10 minutes later, I did see a change; not a massive one, and lines weren’t instantly gone, but overall my skin looked a bit fresher, healthier and stronger. It won’t take the place of Botox for me (no topical skincare product can freeze muscles), but it might just keep me feeling a bit better about my skin until I get my top-up. You can read my full review here.”

SkinCeuticals P-Tiox Neuro-Peptide Serum

£130 from LookFantastic

The brand, adored by beauty editors, skincare experts and dermatologists for cult classic products like C E Ferulic, has introduced this smart serum that features a multi-peptide complex along with PHA, niacinamide and laminaria extract, aiming to target nine different types of wrinkles, from crow’s feet to forehead lines, according to SkinCeuticals.



Laura holding skinceuticals serum

This new serum is a hit with our beauty editor
(Image: Laura Mulley)

Laura says: “P-Tiox is such a dreamy formula: it’s lightweight and runny yet rich, it absorbs instantly yet feels super hydrating (so hydrating that I’ve been skipping moisturiser and going straight to SPF in the mornings), and it layers perfectly with all my other skincare and make-up.

“I’ve only been using this for a week so far but the immediate and short-term results are so impressive that I know I’m already going to be gutted when it runs out. It makes my skin look instantly fresher, plumper and brighter – we’re talking ‘glass skin’ vibes here. It’s a real ‘one-and-done’ anti-ageing serum – you can read my fill review here.”

RoC Derm Correxion Fill + Treat Serum

£39.99 from Sephora

This serum from RoC, a brand loved by celebs such as Jennifer Aniston and Sarah Jessica Parker, contains three types of hyaluronic acid to instantly plump your skin and smooth out lines and wrinkles, plus retinol to boost cell turnover. In RoC’s clinical trials, 97% of participants noted their fine lines and wrinkles appeared plumped and filled within minutes.



Laura holding RoC Derm Correxion wrinkle filler serum skincare

RoC Derm Correxion helps plump and fill surface wrinkles
(Image: Laura Mulley)

One Amazon shopper said: “Love love love love love. In the second week that I’ve been using this. I saw a huge difference in the fine lines on my face. I was skeptical at first but I can’t believe how great this stuff is.”

Hada Labo Tokyo Wrinkle Corrector Eye and Mouth Cream

Was £18.99, now £14.22 from Superdrug

Containing retinol, collagen and four types of hyaluronic acid, this has had shoppers reporting impressive results on wrinkles – especially around the eyes and mouth – in as little as four days.



Laura holding Hada Labo Tokyo Wrinkle Corrector Eye and Mouth Cream

This one has rave reviews from Superdrug shoppers

One Superdrug shopper said: “I had brought this on my friend’s recommendation, I don’t do skincare etc. I had noticed that I was getting smile wrinkles at the end for my eyes; after applying this I noticed the wrinkles had disappeared within four days of using it day and night! Will continue to use it. Highly recommended. Will look into buying what other skin products are available in this brand. 5 stars!”

No7 Laboratories Line Correcting Booster Serum

£34.95 from Boots

Designed to be applied directly to lines and wrinkles for fast, visible results where you want them most, this contains Matrixyl 3000+ and has been proven to visibly reduce the appearance of even the deepest, most stubborn lines and wrinkles.



No7 Laboratories Line Correcting Booster Serum

A popular option from No7
(Image: No7)

OK’s head of beauty Zoe says: “I’m in my thirties so my wrinkles aren’t exactly stubborn, but I do have one on my forehead that really bothers me. I’ve been using this serum for the past two weeks to try to smooth it out, and I’m pleased to report promising results. While the line is still there, there’s been a definite softening of it to a point where it doesn’t bother me quite so much.”

Elemis Pro-Collagen Morning Matrix

£128 from LookFantastic

Part of the brand’s famous Pro-Collagen range, this anti-ageing day cream promises to increase skin firmness and smoothness.



Tester holding Elemis Pro-Collagen Morning Matrix

This Elemis cream got five stars from our tester
(Image: Laura Mulley)

Tester Tracy says: “Wow! I wasn’t sure what to expect and this stuff is amazing! It had the instant effect of a primer and my skin looks great. I usually look half asleep in the day but this has changed all that. I’ve been told my skin looks radiant, brighter and smoother. Seeing a difference with my lines and wrinkles after just a month has been amazing so I will definitely buy this.”

L’Oréal Paris 1.5% Hyaluronic Acid Revitalift Filler Serum

Was £24.99, now £19.99 from LookFantastic

A favourite with celebs such as Molly-Mae Hague, this lightweight serum contains L’Oréal highest concentration of skin-plumping hyaluronic acid to hydrate the skin both at surface level and deeper. The Revitalift eye cream has also been a real hit with shoppers.



Laura holding L'Oréal Paris 1.5% Hyaluronic Acid Revitalift Filler Serum

Part of L’Oréal popular Revitalift range
(Image: Laura Mulley)

Laura says: “I feel like anyone would love this serum; works well with other skincare and instantly makes the face look a little fresher and plumper. It won’t work miracles on deep wrinkles but it’s a great boost for the skin.”

Nivea Q10 Targeted Wrinkle Filler Serum

Was £14.99, now £7.50 from Amazon

Since launching this instant skin smoother has been a sell-out success. It’s now back in stock, and uses Nivea’s famous Q10 complex plus ‘Bioxifill peptides’ to smooth out wrinkles in just five minutes, according to nine out of 10 testers. As well as this instant effect, Nivea claims it also gives long-term results too, with a reduction in wrinkles in the forehead, eye and naso-labial areas after two weeks of use.



Laura holding Nivea Q10 Targeted Wrinkle Filler Serum

Giving smoother skin in just five minutes
(Image: Laura Mulley)

Laura says: “This has an instantly smoothing and blurring effect on fine lines, like Facetune in a tube. It won’t work miracles on very deep wrinkles, but for a quick fix – perhaps before a night out of an important event – it’s great. It’s worth noting that this serum isn’t particularly hydrating so use in addition to your usual serum and/or moisturiser.”

Murad Targeted Wrinkle Corrector

£76 from Murad

Contains peptides that work as instant, temporary ‘filler’ for deep lines, and ingredients to help ward off future lines. It’s also gone viral on TikTok, with shoppers calling it “Botox in a bottle”.



Murad Targeted Wrinkle Corrector

This claims to give instant plus long-term effects
(Image: Murad)

Tester Colleen says: “This product has filled my fine lines on my forehead and my crows feet. Even the very first application my skin looked so much more radiant, healthier and a lot less wrinklier. It’s like some kind of miracle cream! It’s a must have for me now – I look younger and it gives me a plumper appearance without having cosmetic procedures.”

Nivea Expert Lift Cellular Sculpting Sheet Mask

Was £4.99, now £3.79 from Amazon

A 10-minute bakuchiol serum mask made to firm, hydrate and plump skin, reducing the appearance of wrinkles.



Nivea Expert Lift Cellular Sculpting Sheet Mask

Featuring bakuchiol, a plant-based alternative to retinol
(Image: Nivea)

Tester Gail says: “My skin felt really soft, definitely plumper, so much smoother and really hydrated. It’s everything my skin needs and I’ve been admiring my face in the mirror all day. I will definitely be buying more and I’m telling friends about it. I actually feel like I’ve had some sort of expensive facial procedure. Overall my skin looks plumper so there are fewer lines. Finally, an inexpensive product that stands up to the claims it makes. I absolutely love it.”

Vichy Liftactiv Supreme HA Epidermic Filler

Was £43, now £32.25 from Boots

An intensive hyaluronic acid and vitamin serum to plump out skin with moisture and smooth the look of lines.



Vichy Liftactiv Supreme HA Epidermic Filler

Hyaluronic acid helps to plump out fine lines for a smooth finish
(Image: Vichy)

Tester Lisa says: “This left my skin looking lifted and feeling great. The bottle is great for easy application. My skin looks less wrinkly, more youthful and fresh. I absolutely love it.”

Dior Capture Totale Retishot

£92 from Boots

A new targeted retinol treatment from Dior, this serum tackles fine lines as well as texture, uneven skin tone and blemishes. It has a luxuriously silky texture and a gorgeous scent, too.



Laura holding Dior Capture Totale Retishot

Dior’s latest skincare innovation
(Image: Laura Mulley)

One Boots customer wrote: “I was expecting to see results after a few weeks of consistent use, not after just one night! I applied Dior’s new Capture Totale Retishot before bed and woke up with the most softest skin! I can’t even remember the last time my face was this smooth! There was a little redness, but that was to be expected with pure retinol. I’m really excited to continue using this product!”

Luna Microcare Eternal Anti-Wrinkle Under Eye Patches

From £20 from Luna Microcare

A course of stick-on patches with dissolvable micro-channels that deliver anti-ageing ingredients to the delicate under-eye area while you sleep. In the brand’s clinical study, there were “dramatic improvements” to wrinkle depth.



Luna Microcare Eternal Anti-Wrinkle Under Eye Patches

Under-eye patches designed to be worn every night
(Image: Luna)

Tester Rachel says: “Amazing, loved it! A general appearance of tiredness around my eyes causes my makeup not to apply evenly, and makes me look and feel older. After 2-3 weeks of using these, lines around my eyes appeared less pronounced. The whole experience left me feeling more positive as now I don’t look so old and tired. I would definitely would buy this product as I saw a real improvement – the skin under my eyes look fresher and plumper.”

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